Karl Matlin

Professor, Department of Surgery

(773) 834-2242

Karl Matlin is a cell biologist whose laboratory research is focused on the mechanisms by which epithelial cells spatially polarize to form normal epithelia or to directionally migrate during wound repair. He also conducts research on the history of cell and molecular biology, particularly in the post-World War II period. He is particularly interested in how social interactions and the practice of science impact discovery, and on explanatory strategies used by cell and molecular biologists, as well as how these strategies are manifested in the age of genomics, big data, and systems biology. Current projects include a book on the signal hypothesis and its impact on biology.

In Spring 2013 he initiated a new undergraduate and graduate course entitled “A History of Cell and Molecular Biology”.

Publications include:

  • Matlin, K.S. and van Meer, G. Commentaren: Nobelprijs Fysiologie of Geneeskunde 1999 voor de ontedekking dat eiwitten intrinsieke signalen hebben voor transport en lokalisatie binnen de cel. Ned. Tijdschr Geneeskd 1999; 143:2604-2607. (Commentary on the 1999 Nobel Prize in Physiology or Medicine, in Dutch).
  • Matlin, K.S. When cell biology grew up. Traffic 2000; 1:291-292.
  • Matlin, K.S. The strange case of the signal recognition particle. Nat. Rev. Mol. Cell Biol. 2002;3:538-532.
  • Moyano, J.V., Greciano, P.G., Buschmann, M.M., Koch, M., and Matlin, K.S. Autocrine TGFβ activation mediated by integrin αVβ3 regulates transcriptional expression of LM-332 in Madin-Darby canine kidney (MDCK) epithelial cells. Mol. Biol. Cell 2010; 21:3654-3668.
  • Matlin, K.S. Spatial expression of the genome: the signal hypothesis at forty. Nat. Rev. Mol. Cell Biol. 2011;12:333-340.
  • Greciano, PG, Moyano, JV, Buschmann, MM, Tang, J, Lu, Y, Rudnicki, J, Manninen, A, and Matlin, KS. Laminin 511 partners with laminin 332 to mediate directional migration of Madin-Darby canine kidney epithelial cells. Mol. Biol. Cell 2012; 23:121-136.
  • Matlin, K.S. History of the signal hypothesis. 2013. In: eLS. John Wiley and Sons, Ltd. Chichester, in press.